NCL Gene Summary [Human]
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NCL |
| Official Name | nucleolin [Source:HGNC Symbol;Acc:HGNC:7667] |
| Ensembl ID | ENSG00000115053 |
| Bio databases IDs | |
| Aliases | nucleolin |
| Synonyms | B530004O11RIK, C23, D0Nds28, D1Nds28, LOC100289394, Norp, Nrp, Nsr1, NUCL, nucleolin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- pleckstrin Homology binding region
- RGG domain
- histone binding
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- nuclear localization sequence
- calcium ion binding
- enzyme binding
- protein binding
- receptor binding
- sequence-specific DNA binding
- identical protein binding
- acidic domain
- PH-domain binding
- telomeric DNA binding
- RNA binding
- rRNA primary transcript binding
- single-stranded DNA binding
- mRNA 5' UTR binding
- laminin binding
- glycine arginine rich domain
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- breast cancer
- hepatocellular carcinoma
- survival
- idiopathic pulmonary fibrosis
- aortic valve calcification
- Parkinson disease
- noise-induced hearing loss
- pancreatic ductal adenocarcinoma
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- cell viability
- activation in
- binding in
- growth
- binding
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- polyribosome fractions
- detergent resistant lipid raft fraction
- fibrillar center
- cornified envelope
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cell surface
- perinuclear region
- cell cortex
- ribosome
- Plasma Membrane
- granular components
- endosomal membrane
- dense fibrillar component
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleoli
- nuclear matrix
- cellular protrusions
- nucleolar organizers
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of peptidyl-tyrosine phosphorylation
- angiogenesis
- positive regulation of nuclear mRNA splicing, via spliceosome
- cellular response to epidermal growth factor stimulus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of translation
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cornified envelope
- extracellular vesicular exosome
- cell cortex
- membrane
- spliceosomal complex
- chromosome
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- mRNA 5'-UTR binding
- telomeric DNA binding
- insulin receptor substrate binding
- PH domain binding
- DNA topoisomerase binding