CLEC12B Gene Summary [Human]
Enables protein phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CLEC12B |
| Official Name | C-type lectin domain family 12 member B [Source:HGNC Symbol;Acc:HGNC:31966] |
| Ensembl ID | ENSG00000256660 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 12 member B |
| Synonyms | 4933425B16Rik, C-type lectin domain family 12 member B, C-type lectin domain family 12, member B, RGD1560487, UNQ5782 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC12B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- immunoreceptor tyrosine-based inhibition motif
- protein phosphatase binding
- Lectin C-type domain
- receptor inhibitor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC12B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of receptor activity
- natural killer cell inhibitory signaling pathway
- negative regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- receptor inhibitor activity
- protein phosphatase binding
- carbohydrate binding