Clec12b Gene Summary [Mouse]
Predicted to enable protein phosphatase binding activity and signaling receptor inhibitor activity. Predicted to be involved in several processes, including melanocyte proliferation; natural killer cell inhibitory signaling pathway; and regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC12B (C-type lectin domain family 12 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec12b |
| Official Name | C-type lectin domain family 12, member B [Source:MGI Symbol;Acc:MGI:1918433] |
| Ensembl ID | ENSMUSG00000030158 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 12, member B |
| Synonyms | 4933425B16Rik, C-type lectin domain family 12 member B, C-type lectin domain family 12, member B, RGD1560487, UNQ5782 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec12b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- immunoreceptor tyrosine-based inhibition motif
- protein phosphatase binding
- Lectin C-type domain
- receptor inhibitor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec12b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of receptor activity
- natural killer cell inhibitory signaling pathway
- negative regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- receptor inhibitor activity
- protein phosphatase binding
- carbohydrate binding