NR0B2 Gene Summary [Human]
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NR0B2 |
| Official Name | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] |
| Ensembl ID | ENSG00000131910 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 0 group B member 2 |
| Synonyms | nuclear receptor subfamily 0 group B member 2, nuclear receptor subfamily 0, group B, member 2, SHP, SHP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR0B2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- nuclear receptor domain
- LXXLL motif
- retinoic acid receptor binding
- transcription co-repressor
- protein domain specific binding
- protein binding
- thyroid hormone receptor binding
- receptor binding domain
- nuclear receptor ligand binding domain
- transcription repression domain
- peroxisome proliferator activated receptor binding
- binding protein
- ligand-dependent nuclear receptor
- protein homodimerization
- retinoid X receptor binding
- loop domain
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the NR0B2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- insulin resistance
- hypercholesterolemia
- nonalcoholic steatohepatitis
- nonalcoholic fatty liver disease
- hepatic fibrosis
- colon cancer
- dyslipidemia
- biliary atresia
- APC-mutation negative familial colorectal cancer
role in cell
- expression in
- differentiation
- apoptosis
- phosphorylation in
- production in
- activation in
- binding in
- cellular infiltration by
- transcription in
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR0B2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol metabolic process
- negative regulation of sequence-specific DNA binding transcription factor activity
- response to organic cyclic compound
- circadian rhythm
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- response to ethanol
- circadian regulation of gene expression
- response to glucose stimulus
- Notch signaling pathway
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- organ regeneration
- positive regulation of insulin secretion
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein homodimerization activity
- protein binding
- transcription corepressor activity
- transcription factor binding
- retinoid X receptor binding
- thyroid hormone receptor binding
- peroxisome proliferator activated receptor binding