GOLM1 Gene Summary [Human]
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | GOLM1 |
| Official Name | golgi membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:15451] |
| Ensembl ID | ENSG00000135052 |
| Bio databases IDs | |
| Aliases | golgi membrane protein 1 |
| Synonyms | 2310001L02Rik, bA379P1.3, C9orf155, D030064E01Rik, golgi membrane protein 1, golgi phosphoprotein 2, GOLPH2, GP73, HEL46, LOC100293491, PSEC0257 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOLM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- COVID-19
- acute-on-chronic liver failure
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- hepatic fibrosis
role in cell
- expression in
- accumulation in
- proliferation
- phosphorylation in
- invasion by
- migration
- downregulation in
- S phase
- organization
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOLM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid metabolic process
- nucleus organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding