MLLT6 Gene Summary [Human]
Enables histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of histone H3-K79 methylation; renal potassium excretion; and renal sodium excretion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MLLT6 |
| Official Name | MLLT6, PHD finger containing [Source:HGNC Symbol;Acc:HGNC:7138] |
| Ensembl ID | ENSG00000275023 |
| Bio databases IDs | |
| Aliases | MLLT6, PHD finger containing, Myeloid/lymphoid or mixed-lineage leukemia, translocated to, 6, trithorax homolog |
| Synonyms | AF17, AI315037, MLLT6, PHD finger containing, myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 6, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MLLT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- PHD-like zinc-binding domain
- binding protein
- chromatin binding
- PHD finger superfamily
- leucine zipper domain
- protein binding
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MLLT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal water absorption
- negative regulation of urine volume
- positive regulation of sodium ion transport
- renal sodium excretion
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone binding
- nucleosome binding