TLE5 Gene Summary [Human]
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TLE5 |
| Official Name | TLE family member 5, transcriptional modulator [Source:HGNC Symbol;Acc:HGNC:307] |
| Ensembl ID | ENSG00000104964 |
| Bio databases IDs | |
| Aliases | TLE family member 5, transcriptional modulator |
| Synonyms | AES, AES-1, ESP1, GAM, GRG, GRG5, TLE family member 5, transcriptional modulator |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLE5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- Groucho/TLE N-terminal Q-rich domain
- protein binding
- glutamine-rich domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- growth failure
- systemic autoimmune syndrome
- infection by HIV-1
role in cell
- proliferation
- apoptosis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLE5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- negative regulation of response to cytokine stimulus
- skeletal system development
- negative regulation of transcription, DNA-dependent
- response to interleukin-1
- Wnt receptor signaling pathway
- positive regulation of anoikis
- negative regulation of protein binding
- regulation of growth
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity