MYB Gene Summary [Human]
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | MYB |
| Official Name | MYB proto-oncogene, transcription factor [Source:HGNC Symbol;Acc:HGNC:7545] |
| Ensembl ID | ENSG00000118513 |
| Bio databases IDs | |
| Aliases | MYB proto-oncogene, transcription factor |
| Synonyms | c-MYB, c-myb CDS, efg, MYB proto-oncogene, transcription factor, myeloblastosis oncogene, RGD1560020 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Sumoylation motif
- transcription activation domain
- negative regulation of DNA-binding domain
- Myb repeat
- Myb-like DNA-binding domain
- LMSTEN motif
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- leucine rich domain
- acetylation site
- DNA binding domain
- nucleic acid binding
- negative regulatory domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- C-myb, C-terminal
- DNA binding
- conserved domain
- double-stranded DNA binding
- GT1, myb-like, SANT family
- transcription factor activity
- SUMO-1 modification site
Pathways
Biological processes and signaling networks where the MYB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- epithelial cancer
- cancer
- B-cell childhood acute lymphoblastic leukemia
- metastasis
- HER2 negative hormone receptor negative breast cancer
- colorectal cancer
- chronic lymphocytic leukemia
- T acute lymphoblastic leukemia
role in cell
- formation
- apoptosis
- degradation in
- growth
- expression in
- differentiation
- survival
- cell death
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hepatic stellate cell activation
- positive regulation of glial cell proliferation
- regulation of transcription, DNA-dependent
- negative regulation of megakaryocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- mitotic cell cycle
- positive regulation of smooth muscle cell proliferation
- negative regulation of transcription from RNA polymerase II promoter
- T-helper 2 cell differentiation
- positive regulation of collagen biosynthetic process
- response to ischemia
- erythrocyte differentiation
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- cellular response to retinoic acid
- positive regulation of testosterone secretion
- positive regulation of transcription, DNA-dependent
- skeletal muscle cell proliferation
- cellular response to hydrogen peroxide
- positive regulation of transforming growth factor beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear matrix
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity