CREB5 Gene Summary [Human]
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CREB5 |
| Official Name | cAMP responsive element binding protein 5 [Source:HGNC Symbol;Acc:HGNC:16844] |
| Ensembl ID | ENSG00000146592 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein 5, cAMP response element binding protein CRE-Bpa |
| Synonyms | 9430076C15Rik, cAMP responsive element binding protein 5, CRE-BPA, D430026C09Rik, LOC100910345, LOC401317, RGD1566107 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CREB5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- bZIP
- transcription factor activity
- identical protein binding
- basic region leucin zipper
- bZIP domain
Pathways
Biological processes and signaling networks where the CREB5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Calcium Signaling
- Corticotropin Releasing Hormone Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Synaptic Long Term Potentiation
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- neoplasia
- acute myeloid leukemia
- HER2 negative hormone receptor negative breast cancer
- breast carcinoma
- open-angle glaucoma
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- diabetic peripheral neuropathy
- atrial fibrillation
role in cell
- expression in
- growth
- migration
- differentiation
- mitochondrial cell death
- size
- cisplatin sensitivity
- invasion by
- transactivation in
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CREB5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- chromatin
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity