NUDT18 Gene Summary [Human]
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Details
| Type | Protein Coding |
| Official Symbol | NUDT18 |
| Official Name | nudix hydrolase 18 [Source:HGNC Symbol;Acc:HGNC:26194] |
| Ensembl ID | ENSG00000275074 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 18, mutT human homolog 3 |
| Synonyms | MTH3, nudix hydrolase 18, RGD1311802 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDT18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- NUDIX domain
- enzyme
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDT18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleobase-containing small molecule metabolic process
- dADP catabolic process
- dGDP catabolic process
- GDP catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding