Nudt18 Gene Summary [Mouse]
Predicted to enable 8-hydroxy-dADP phosphatase activity; 8-oxo-GDP phosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Is expressed in several structures, including central nervous system; embryo endoderm; and retina. Orthologous to human NUDT18 (nudix hydrolase 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt18 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 18 [Source:MGI Symbol;Acc:MGI:2385853] |
| Ensembl ID | ENSMUSG00000045211 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
| Synonyms | MTH3, nudix hydrolase 18, RGD1311802 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- NUDIX domain
- enzyme
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleobase-containing small molecule metabolic process
- dADP catabolic process
- dGDP catabolic process
- GDP catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding