Clcn4 Gene Summary [Mouse]
Predicted to enable antiporter activity and voltage-gated chloride channel activity. Involved in non-motile cilium assembly. Is active in ciliary base. Is expressed in cortical plate; early conceptus; heart; heart ventricle; and oocyte. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (chloride voltage-gated channel 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcn4 |
| Official Name | chloride channel, voltage-sensitive 4 [Source:MGI Symbol;Acc:MGI:104571] |
| Ensembl ID | ENSMUSG00000000605 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive 4 |
| Synonyms | chloride channel, voltage-sensitive 4, chloride voltage-gated channel 4, CLC4, Clc4-2, ClC-4A, Clcn4-2, MRX15, MRX49, MRXSRC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- antiporter
- protein binding
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- X-linked mental retardation
- CLCN4-related disorder
- nonsyndromic X-linked mental retardation
- x-linked mental retardation type 49
- glioblastoma
- glioblastoma cancer
regulates
- chloride
- ion
role in cell
- survival
- migration
- motility
- invasion by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- apical membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clcn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- chloride transport
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- Golgi apparatus
- lysosomal membrane
- plasma membrane
- endoplasmic reticulum membrane
- early endosome membrane
- late endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- endosome membrane
- recycling endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- antiporter activity
- chloride channel activity
- voltage-gated chloride channel activity