Mtap Gene Summary [Mouse]
Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Acts upstream of or within methylation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtap |
| Official Name | methylthioadenosine phosphorylase [Source:MGI Symbol;Acc:MGI:1914152] |
| Ensembl ID | ENSMUSG00000062937 |
| Bio databases IDs | |
| Aliases | methylthioadenosine phosphorylase |
| Synonyms | 1300019I21Rik, BDMF, c86fus, Cc1-6, DMSFH, DMSMFH, HEL-249, LGMBF, methylthioadenosine phosphorylase, MSAP, MTA phosphorylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5'-methylthioadenosine phosphorylase
- nucleoside phosphorylase-I family
- enzyme
- protein binding
- phosphorylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- non-small cell lung cancer
- cutaneous melanoma
- neoplasia
- squamous cell cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- myocardial infarction
role in cell
- expression in
- growth
- cellular infiltration by
- stabilization in
- synthesis in
- serine phosphorylation in
- threonine phosphorylation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-methionine salvage from methylthioadenosine
- nicotinamide riboside catabolic process
- purine ribonucleoside salvage
- response to testosterone stimulus
- nucleobase-containing compound metabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphorylase activity
- S-methyl-5-thioadenosine phosphorylase activity
- protein binding