Clcn3 Gene Summary [Mouse]
Enables antiporter activity. Involved in synaptic vesicle lumen acidification. Acts upstream of or within several processes, including chemical synaptic transmission; photoreceptor cell maintenance; and positive regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including endosome membrane; lysosomal membrane; and synaptic vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and heart. Used to study neuronal ceroid lipofuscinosis 3. Orthologous to human CLCN3 (chloride voltage-gated channel 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcn3 |
| Official Name | chloride channel, voltage-sensitive 3 [Source:MGI Symbol;Acc:MGI:103555] |
| Ensembl ID | ENSMUSG00000004319 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive 3 |
| Synonyms | chloride channel, voltage-sensitive 3, chloride voltage-gated channel 3, CLC3, NEDHYBA, NEDSBA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- volume-sensitive anion channel
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- protein binding
- ion channel
- PDZ-domain binding
- CBS_pair_SF
- chloride channel
- antiporter
- voltage-gated ion channel
- voltage-gated chloride channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- hippocampal atrophy
- amyotrophic lateral sclerosis
- non-small cell lung cancer
- schizophrenia
- asthma
- non-small cell lung carcinoma
- kyphoscoliosis
- tremor
- neurodevelopmental disorder with seizures and brain abnormalities
role in cell
- expression in
- migration
- expansion
- number
- volume
- abnormal morphology
- function
- chemotaxis
- degeneration
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomal fractions
- synaptic vesicle membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cell surface
- intracellular membranes
- cellular membrane
- endosomes
- vesicles
- Golgi Apparatus
- granules
- vesicle membrane
- plasma membrane extracellular face
- apical membrane
- postsynaptic membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- nerve ending
- synapse
- recycling endosomes
- early endosomes
- late endosomes
- cytoplasmic vesicles
- synaptic-like microvesicles
- specific granules
- secretory granules
- cell membrane leading edge
- axon terminals
- phagosomes
- lamellipodia
- mossy fibers
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clcn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagocytosis, engulfment
- negative regulation of cell volume
- photoreceptor cell maintenance
- endosomal lumen acidification
- adult locomotory behavior
- synaptic transmission, GABAergic
- regulation of pH
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- secretory granule
- synaptic vesicle
- late endosome
- phagocytic vesicle
- external side of plasma membrane
- Golgi membrane
- Golgi apparatus
- axon terminus
- plasma membrane
- lysosomal membrane
- cell surface
- early endosome membrane
- late endosome membrane
- early endosome
- specific granule
- vesicle membrane
- intracellular membrane-bounded organelle
- membrane
- ruffle membrane
- cytoplasmic vesicle
- endosome membrane
- recycling endosome
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- antiporter activity
- volume-sensitive chloride channel activity
- PDZ domain binding
- chloride channel activity
- voltage-gated chloride channel activity