Tmem9 Gene Summary [Mouse]
Involved in positive regulation of canonical Wnt signaling pathway and regulation of protein catabolic process. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Is expressed in central nervous system; retina; small intestine; and tooth. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem9 |
| Official Name | transmembrane protein 9 [Source:MGI Symbol;Acc:MGI:1913491] |
| Ensembl ID | ENSMUSG00000026411 |
| Bio databases IDs | |
| Aliases | transmembrane protein 9 |
| Synonyms | 1500015G18Rik, DERM4, DERP4, DKFZP564I1216, HSPC186, TMEM9A, transmembrane protein 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TMEM9
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- endosomes
- lysosome
- cytoplasmic bridges
- lysosome membrane
- late endosomes
- multivesicular bodies
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosomal lumen acidification
- protein transport
- lysosomal lumen acidification
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of protein catabolic process
- proton-transporting V-type ATPase complex assembly
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- intercellular bridge
- mitotic spindle
- intracellular membrane-bounded organelle
- late endosome
- multivesicular body membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding