Mcm3ap Gene Summary [Mouse]
Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and histone binding activity. Predicted to be involved in nucleosome organization; poly(A)+ mRNA export from nucleus; and somatic hypermutation of immunoglobulin genes. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm3ap |
| Official Name | minichromosome maintenance complex component 3 associated protein [Source:MGI Symbol;Acc:MGI:1930089] |
| Ensembl ID | ENSMUSG00000001150 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 3 associated protein |
| Synonyms | GANP, MAP80, minichromosome maintenance complex component 3 associated protein, Mini chromosome maintenance deficient 3 associated, PNRIID, SAC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm3ap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- RNA recognition motif (RRM) superfamily
- SAC3/GANP family
- histone acetyltransferase
- RNA recognition motif
- Nucleoporin FG repeat region
- chromatin binding
- enzyme
- protein binding
- Binding region of GANP to ENY2
- MCM3AP domain of GANP
- Nucleoporin homology of Germinal-centre associated nuclear protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive peripheral neuropathy without impaired intellectual development
- hereditary disorder
- autosomal recessive peripheral neuropathy with or without impaired intellectual development
- autosomal recessive peripheral neuropathy with impaired intellectual development
- lymphomagenesis
- pervasive developmental disorder
- infection by Influenza A virus subtype H1N1
regulates
- histone H2B
role in cell
- synthesis in
- organization
- breakage in
- homologous recombination in
- development
- CSN5i-3 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm3ap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleosome organization
- protein transport
- poly(A)+ mRNA export from nucleus
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- cytosol
- chromosome
- transcription export complex 2
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- histone acetyltransferase activity
- H3 histone acetyltransferase activity
- protein binding
- histone binding
- chromatin binding