Cdc73 Gene Summary [Mouse]
Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc73 |
| Official Name | cell division cycle 73, Paf1/RNA polymerase II complex component [Source:MGI Symbol;Acc:MGI:2384876] |
| Ensembl ID | ENSMUSG00000026361 |
| Bio databases IDs | |
| Aliases | cell division cycle 73, Paf1/RNA polymerase II complex component |
| Synonyms | 8430414L16RIK, BC027756, C130030P16Rik, C1orf28, C81219, cell division cycle 73, cell division cycle 73, Paf1/RNA polymerase II complex component, FIHP, HPRT2, HPTJT, HRPT1, HRPT2, HYX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc73 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paf1 complex subunit CDC73 N-terminal
- RNA pol II accessory factor, Cdc73 family, C-terminal
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mixed neoplasia
- renal neoplasia
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- head and neck cancer
- breast cancer
- aortic valve calcification
- hereditary cancer-predisposing syndrome
role in cell
- expression in
- proliferation
- apoptosis
- growth
- phosphorylation in
- replication in
- differentiation
- binding in
- transactivation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc73 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- negative regulation of myeloid cell differentiation
- negative regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- protein destabilization
- positive regulation of transcription elongation from RNA polymerase II promoter
- cellular response to lipopolysaccharide
- endodermal cell fate commitment
- regulation of cell growth
- negative regulation of fibroblast proliferation
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- positive regulation of mRNA 3'-end processing
- Wnt receptor signaling pathway
- mRNA 3'-end processing
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- Cdc73/Paf1 complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core binding