Trim37 Gene Summary [Mouse]
The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Trim37 |
| Official Name | tripartite motif-containing 37 [Source:MGI Symbol;Acc:MGI:2153072] |
| Ensembl ID | ENSMUSG00000018548 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 37 |
| Synonyms | 1110032A10Rik, 2810004E07Rik, MUL, POB1, TEF3, tripartite motif-containing 37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- ubiquitin protein ligase binding
- transcription co-activator
- B-Box C-terminal domain
- MATH
- tumor necrosis factor receptor binding
- ubiquitin protein ligase activity
- chromatin binding
- enzyme
- TRAF domain
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- protein homodimerization
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- hepatic injury
- non-insulin-dependent diabetes mellitus
- mulibrey nanism
- renal cell carcinoma
- renal cell cancer
- advanced cancer
- organismal death
role in cell
- survival
- phosphorylation in
- apoptosis
- growth
- cell death
- expression in
- proliferation
- activation in
- migration
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- Nucleus
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- negative regulation of gene expression, epigenetic
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of centriole replication
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein monoubiquitination
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- aggresome assembly
- protein stabilization
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- perinuclear region of cytoplasm
- cytoplasm
- ESC/E(Z) complex
- cytosol
- chromosome
- aggresome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- ubiquitin protein ligase binding
- protein homodimerization activity
- transcription coactivator activity
- tumor necrosis factor receptor binding
- chromatin binding