Fbxo9 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within fat cell differentiation and innate immune response. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; and liver. Orthologous to human FBXO9 (F-box protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo9 |
| Official Name | f-box protein 9 [Source:MGI Symbol;Acc:MGI:1918788] |
| Ensembl ID | ENSMUSG00000001366 |
| Bio databases IDs | |
| Aliases | f-box protein 9 |
| Synonyms | 9030401P18Rik, dJ341E18.2, F-box protein 9, FBX9, FBXO6, NY-REN-57, NY-REN-57 antigen, VCIA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- protein binding activity, bridging
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- innate immune response
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- fat cell differentiation
- protein ubiquitination
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding