Cops5 Gene Summary [Mouse]
Enables enzyme binding activity and macrophage migration inhibitory factor binding activity. Acts upstream of or within regulation of cell cycle. Part of COP9 signalosome. Is expressed in several structures, including 1st branchial arch; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops5 |
| Official Name | COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:MGI:1349415] |
| Ensembl ID | ENSMUSG00000025917 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 5 |
| Synonyms | COP9 signalosome subunit 5, CSN5, JAB1, JUN ACTIVATION domain binding, MOV-34, SGN5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cop9 signalosome subunit 5 C-terminal domain
- transcription regulator
- cytokine binding
- nuclear export signal
- transcription co-activator
- enzyme binding
- protein binding
- metallopeptidase
- JAB/MPN domain
- NEDD8-specific protease
- Mpr1p, Pad1p N-terminal (MPN) domains
- translation initiation factor
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Cops5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- infection
- atherosclerosis
- obesity
- epithelial cancer
- cancer
- motor dysfunction
- osteosarcomagenesis
- organismal death
- axonal degeneration
role in cell
- expression in
- growth
- translation in
- phosphorylation in
- apoptosis
- activation
- activation in
- transactivation in
- proliferation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell periphery
- perinuclear region
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- perinuclear space
- nucleoli
- synaptic vesicles
- chromatin
- exosomes
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deneddylation
- protein neddylation
- positive regulation of sequence-specific DNA binding transcription factor activity
- translational initiation
- positive regulation of transcription from RNA polymerase II promoter
- post-translational protein modification
- translation
- regulation of JNK cascade
- negative regulation of apoptotic process
- proteolysis
- regulation of cell cycle
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- synaptic vesicle
- cytosol
- signalosome
- chromatin
- eukaryotic translation initiation factor 3 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- macrophage migration inhibitory factor binding
- NEDD8-specific protease activity
- metallopeptidase activity
- enzyme binding