Carm1 Gene Summary [Mouse]
Enables several functions, including lysine-acetylated histone binding activity; protein-arginine N-methyltransferase activity; and transcription coactivator activity. Involved in nuclear receptor-mediated steroid hormone signaling pathway; positive regulation of fat cell differentiation; and regulation of intracellular estrogen receptor signaling pathway. Acts upstream of or within several processes, including estrogen receptor signaling pathway; regulation of DNA-templated transcription; and regulation of growth plate cartilage chondrocyte proliferation. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; gonad; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Carm1 |
| Official Name | coactivator-associated arginine methyltransferase 1 [Source:MGI Symbol;Acc:MGI:1913208] |
| Ensembl ID | ENSMUSG00000032185 |
| Bio databases IDs | |
| Aliases | coactivator-associated arginine methyltransferase 1 |
| Synonyms | coactivator-associated arginine methyltransferase 1, m9Bei, PRMT4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Carm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- activation domain
- transcription regulator
- transcription co-activator
- nucleic acid binding
- beta-catenin binding
- PRMT5 arginine-N-methyltransferase
- transcription activation domain
- transcription factor binding
- enzyme
- protein binding
- Pleckstrin homology-like domain
- AdoMet_MTases
- protein-arginine N-methyltransferase
- sequence-specific DNA binding
- methyltransferase domain
- phosphorylation site
- histone-arginine N-methyltransferase
- protein methyltransferase
- histone methyltransferase
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Carm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- lung squamous cell carcinoma
- squamous cell lung cancer
- breast cancer
- plasma cell myeloma
- prostate cancer
- acute coronary syndrome
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- transcription in
- differentiation
- phosphorylation in
- binding in
- cell proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Carm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- chromatin remodeling
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- response to cAMP
- positive regulation of fat cell differentiation
- regulation of intracellular estrogen receptor signaling pathway
- replication fork reversal
- methylation
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear replication fork
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- protein methyltransferase activity
- transcription regulatory region sequence-specific DNA binding
- beta-catenin binding
- histone-arginine N-methyltransferase activity
- protein binding
- transcription coactivator activity
- histone methyltransferase activity
- histone acetyl-lysine binding
- protein-arginine N-methyltransferase activity
- ligand-dependent nuclear receptor transcription coactivator activity
- histone methyltransferase activity (H3-R2 specific)
- histone methyltransferase activity (H3-R17 specific)