Trmt1 Gene Summary [Mouse]
Predicted to enable tRNA (guanine(26)-N2)-dimethyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Trmt1 |
| Official Name | tRNA methyltransferase 1 [Source:MGI Symbol;Acc:MGI:1289155] |
| Ensembl ID | ENSMUSG00000001909 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase 1 |
| Synonyms | 6720406L13Rik, 6720477L24, D8Ertd812e, MRT68, RGD1305992, TRM1, tRNA methyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- tRNA (guanine) methyltransferase
- N2,N2-dimethylguanosine tRNA methyltransferase
- tRNA(guanine-26,N2-N2) methyltransferase
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- zinc finger domain
- AdoMet_MTases
- N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- tRNA binding