Dpp9 Gene Summary [Mouse]
Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to act upstream of with a negative effect on pyroptotic inflammatory response. Predicted to be located in cell leading edge and microtubule. Predicted to be active in cytosol. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dpp9 |
| Official Name | dipeptidylpeptidase 9 [Source:MGI Symbol;Acc:MGI:2443967] |
| Ensembl ID | ENSMUSG00000001229 |
| Bio databases IDs | |
| Aliases | dipeptidylpeptidase 9 |
| Synonyms | 6430584G11RIK, A330078I11, dipeptidyl peptidase 9, DP9, DPLP9, DPP IX, DPRP-2, HATIS, IMD111 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- alpha/beta hydrolase fold domain
- peptidase
- dipeptidyl-peptidase
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- interstitial lung disease
- idiopathic pulmonary fibrosis
- COVID-19
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Hatipoglu immunodeficiency syndrome
- organismal death
- viral respiratory infection
- critical COVID-19
- severe COVID-19
regulated by
- NLRP1
- DPP9
- dithiothreitol
role in cell
- expression in
- proliferation
- cell death
- apoptosis
- activation in
- accumulation in
- survival
- binding in
- inhibition in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- pyroptosis
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell leading edge
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- serine-type peptidase activity
- aminopeptidase activity
- dipeptidyl-peptidase activity