Kdm5a Gene Summary [Mouse]
Enables several functions, including chromatin DNA binding activity; histone H3K4 demethylase activity; and transcription coactivator activity. Involved in circadian regulation of gene expression and facultative heterochromatin formation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including 1st branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in ankylosing spondylitis. Orthologous to human KDM5A (lysine demethylase 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Kdm5a |
| Official Name | lysine (K)-specific demethylase 5A [Source:MGI Symbol;Acc:MGI:2136980] |
| Ensembl ID | ENSMUSG00000030180 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 5A |
| Synonyms | JARID1A, lysine demethylase 5A, NEDEHC, RBBP-2, RBP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription co-activator
- jmjN domain
- nucleic acid binding
- PLU-1-like protein
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme inhibitor activity
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- ARID/BRIGHT DNA binding domain
- RmlC-like cupin superfamily
- DNA binding
- PHD-finger
- C5HC2 zinc finger
- zinc ion binding
- double-stranded DNA binding
- PHD finger superfamily
- histone demethylase activity
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- neoplasia
- tumorigenesis
- lung squamous cell carcinoma
- squamous cell lung cancer
- metastasis
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
- gastric epithelial cancer
- brain cancer
role in cell
- expression in
- function
- proliferation
- number
- migration
- growth
- invasion
- colony formation by
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- circadian regulation of gene expression
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- DNA binding
- zinc ion binding
- protein binding
- transcription coactivator activity
- histone binding
- enzyme inhibitor activity
- methylated histone residue binding
- transcription regulatory region sequence-specific DNA binding
- histone demethylase activity
- histone demethylase activity (H3-trimethyl-K4 specific)