Mrpl2 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL2 (mitochondrial ribosomal protein L2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrpl2 |
| Official Name | mitochondrial ribosomal protein L2 [Source:MGI Symbol;Acc:MGI:1351622] |
| Ensembl ID | ENSMUSG00000002767 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosomal protein L2 |
| Synonyms | CGI-22, L2mt, mitochondrial ribosomal protein L2, MRP-L14, RPML14, uL2m |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrpl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal Proteins L2, RNA binding domain
- structural constituent of ribosome
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- cutaneous melanoma cancer
- insulin resistance
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ribosome
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrpl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- structural constituent of ribosome