Fbxl6 Gene Summary [Mouse]
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL6 (F-box and leucine rich repeat protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl6 |
| Official Name | F-box and leucine-rich repeat protein 6 [Source:MGI Symbol;Acc:MGI:1354705] |
| Ensembl ID | ENSMUSG00000022559 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 6 |
| Synonyms | FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, PP14630 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- activation in
- expression in
- migration
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity