Oxa1l Gene Summary [Mouse]
Predicted to enable membrane insertase activity; mitochondrial ribosome binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial protein quality control; mitochondrion organization; and protein tetramerization. Located in mitochondrial inner membrane. Orthologous to human OXA1L (OXA1L mitochondrial inner membrane protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Oxa1l |
| Official Name | oxidase assembly 1-like [Source:MGI Symbol;Acc:MGI:1916339] |
| Ensembl ID | ENSMUSG00000000959 |
| Bio databases IDs | |
| Aliases | oxidase assembly 1-like |
| Synonyms | 1810020M02Rik, LOC678917, OXA1, OXA1L1, OXA1L mitochondrial inner membrane protein, OXA1L, mitochondrial inner membrane protein, oxidase assembly 1-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oxa1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK00145
- membrane protein insertase, YidC/Oxa1 family, C-terminal domain
- Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases
- 60Kd inner membrane protein
- ribosome binding
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial disorder
regulates
- cytochrome-c oxidase
- ATPase
- Mitochondrial ETC 1
role in cell
- mass
- autophagy in
- respiration in
- autophagy
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oxa1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into mitochondrial membrane from inner side
- negative regulation of oxidoreductase activity
- mitochondrial proton-transporting ATP synthase complex assembly
- negative regulation of ATPase activity
- protein tetramerization
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial matrix
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- mitochondrial ribosome binding
- membrane insertase activity
- protein binding
- protein homodimerization activity