Dock8 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Involved in dendritic cell migration; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Acts upstream of or within immunological synapse formation and negative regulation of T cell apoptotic process. Located in cell leading edge. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in atopic dermatitis; bacterial infectious disease; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock8 |
| Official Name | dedicator of cytokinesis 8 [Source:MGI Symbol;Acc:MGI:1921396] |
| Ensembl ID | ENSMUSG00000052085 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 8 |
| Synonyms | 1200017A24RIK, 5830472H07RIK, A130095G14RIK, dedicator of cytokinesis 8, HEL-205, HIES2, MRD2, ZIR8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- Dedicator of cytokinesis C/D, N terminal
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- DHR-2, Lobe A
- guanyl-nucleotide exchange factor
- DOCK homology region 2
- protein binding
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- hereditary disorder
- autosomal recessive hyper-IgE recurrent infection syndrome
- DOCK8 deficiency
- male pattern hair loss
- severe COVID-19
- coronary artery disease
- autosomal recessive hyper-IgE recurrent infection syndrome 2
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- activity
- proliferation
- apoptosis
- quantity
- formation
- migration
- cytotoxicity
- survival
- production in
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- lysosome
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell migration
- small GTPase mediated signal transduction
- negative regulation of T cell apoptotic process
- regulation of small GTPase mediated signal transduction
- immunological synapse formation
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cell leading edge
- cytoplasm
- membrane
- cytosol
- leading edge membrane
- plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity