Tbc1d8 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Is expressed in several structures, including alimentary system; central nervous system; limb segment; sensory organ; and urinary system. Orthologous to human TBC1D8 (TBC1 domain family member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d8 |
| Official Name | TBC1 domain family, member 8 [Source:MGI Symbol;Acc:MGI:1927225] |
| Ensembl ID | ENSMUSG00000003134 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 8 |
| Synonyms | AD3, GRAMD8, HBLP1, IHoP, LOC100364476, LOC101927271, LOC681648, RAB-GAP/TBC, TBC1D8A, TBC1 domain family member 8, TBC1 domain family, member 8, VRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbc1d8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbc1d8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- blood circulation
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity