Abhd17a Gene Summary [Mouse]
Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and regulation of protein localization. Predicted to be located in nuclear speck; postsynaptic density; and recycling endosome membrane. Predicted to be active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abhd17a |
| Official Name | abhydrolase domain containing 17A [Source:MGI Symbol;Acc:MGI:106388] |
| Ensembl ID | ENSMUSG00000003346 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 17A |
| Synonyms | 1700013O15Rik, abhydrolase domain containing 17A, abhydrolase domain containing 17A, depalmitoylase, C19orf27, D10Bwg1364e, Fam108a, FAM108A1, RGD1359682, upf0227 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abhd17a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Phospholipase/Carboxylesterase
- Serine aminopeptidase, S33
- enzyme
- protein binding
- palmitoyl-(protein) hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- synaptic membrane
- endosomal membrane
- nuclear speckles
- recycling endosomes
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abhd17a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein depalmitoylation
- protein localization in membrane
- negative regulation of NLRP3 inflammasome complex assembly
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- nuclear speck
- membrane
- dendritic spine
- endosome membrane
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- palmitoyl-(protein) hydrolase activity