Tcp1 Gene Summary [Mouse]
Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in several cellular components, including acrosomal vesicle; heterochromatin; and pericentriolar material. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including cerebral cortex; extraembryonic component; genitourinary system; humerus; and immune system. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tcp1 |
| Official Name | t-complex protein 1 [Source:MGI Symbol;Acc:MGI:98535] |
| Ensembl ID | ENSMUSG00000068039 |
| Bio databases IDs | |
| Aliases | t-complex protein 1 |
| Synonyms | c-cpn, CCT, CCT1, CCTa, CCT-alpha, CCT-α, D6S230E, IDDPMGS, LOC435546, p63, t-complex 1, T complex protein 1, T-COMPLEX protein 1, alpha subunit, T-complex protein 1 alpha subunit b, T-complex protein 1 alpha subunits A+B, T-COMPLEX protein 1, α subunit, T-complex protein 1 α subunit b, T-complex protein 1 α subunits A+B, TCP-1-alpha, TCP-1-α, Tp63, TRic |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- apical domain
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- idiopathic scoliosis
- colon carcinoma
- colon epithelial cancer
- Kawasaki disease
regulated by
- caffeic acid phenethyl ester
- camptothecin
- secondhand smoke
- ZNF76
- gamma-secretase inhibitor compound E
- E1
- K+
- BCR (complex)
- STAT4 dimer
- HSF1
role in cell
- expression in
- mitosis
- proliferation
- apoptosis
- growth
- cell viability
- survival
- activation in
- binding
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- heterochromatin
- basal compartment
- Nucleus
- centrosome
- Golgi Apparatus
- microtubules
- microtubule organizing centers
- cytosol
- acrosome
- perikaryon
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- binding of sperm to zona pellucida
- tubulin complex assembly
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- chaperonin-containing T-complex
- pericentriolar material
- centrosome
- extracellular vesicular exosome
- acrosomal vesicle
- cell body
- cytosol
- Golgi apparatus
- sperm protein complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein binding involved in protein folding
- ubiquitin protein ligase binding
- RNA binding
- unfolded protein binding