Pex19 Gene Summary [Mouse]
Predicted to enable ATPase binding activity; peroxisome membrane class-1 targeting sequence binding activity; and protein carrier chaperone. Predicted to be involved in chaperone-mediated protein folding; peroxisome organization; and protein stabilization. Predicted to be located in several cellular components, including brush border membrane; nucleoplasm; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Is expressed in several structures, including nervous system; tail; and trunk. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex19 |
| Official Name | peroxisomal biogenesis factor 19 [Source:MGI Symbol;Acc:MGI:1334458] |
| Ensembl ID | ENSMUSG00000003464 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 19 |
| Synonyms | D1S2223E, HK33, LOC100911356, PBD12A, Peroxin 19, peroxisomal biogenesis factor 19, PEX19p, PMP1, PMPI, PXF, PXMP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pex19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxisome targeting sequence binding
- ATPase binding
- CAAX box
- protein binding
- Pex19 protein family
- farnesylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peroxisome biogenesis disorder 12a (zellweger)
- hereditary disorder
- psoriasis
- Zellweger syndrome
- peroxisome biogenesis disorder
- breast cancer
role in cell
- biogenesis
- fission
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- peroxisome membrane
- nucleoplasm
- peroxisomes
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pex19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peroxisome fission
- protein targeting to peroxisome
- negative regulation of lipid binding
- protein import into peroxisome membrane
- establishment of protein localization to peroxisome
- peroxisome organization
- chaperone-mediated protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- brush border membrane
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- peroxisome membrane targeting sequence binding
- peroxisome membrane class-1 targeting sequence binding
- ATPase binding