Tomm20 Gene Summary [Mouse]
Predicted to enable mitochondrion targeting sequence binding activity; protein-transporting ATPase activity; and unfolded protein binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Located in migrasome; mitochondrial envelope; and sperm midpiece. Is active in cell periphery. Is expressed in several structures, including central nervous system; genitourinary system; heart; and liver. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tomm20 |
| Official Name | translocase of outer mitochondrial membrane 20 [Source:MGI Symbol;Acc:MGI:1915202] |
| Ensembl ID | ENSMUSG00000093904 |
| Bio databases IDs | |
| Aliases | translocase of outer mitochondrial membrane 20 |
| Synonyms | 1810060K07Rik, Gm19268, LOC266601, MAS20, mKIAA0016, MOM19, TOM20, translocase of outer mitochondrial membrane 20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tomm20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MAS20 protein import receptor
- mitochondrial presequence
- protein translocase
- cytoplasmic domain
- protein binding
- cytosolic tail domain
- signal sequence binding
- transporter
Pathways
Biological processes and signaling networks where the Tomm20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early age-related maculopathy
- metastasis
- Huntington disease
role in cell
- apoptosis
- expression in
- sphere formation by
- dysfunction
- enzalutamide sensitivity
- bicalutamide resistance
- bicalutamide sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- mitochondrial envelope
- cell periphery
- Mitochondria
- mitochondrial outer membrane
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tomm20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein import into mitochondrial outer membrane
- protein import into mitochondrial matrix
- tRNA import into mitochondrion
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- mitochondrion
- ER-mitochondrion membrane contact site
- mitochondrial outer membrane
- cell periphery
- mitochondrial outer membrane translocase complex
Molecular Function
What the gene product does at the molecular level
- mitochondrion targeting sequence binding
- protein binding
- protein transmembrane transporter activity
- P-P-bond-hydrolysis-driven protein transmembrane transporter activity
- unfolded protein binding