Plaat3 Gene Summary [Mouse]
Enables phospholipase A1 activity and phospholipase A2 activity. Involved in several processes, including ether lipid metabolic process; lens fiber cell differentiation; and regulation of adipose tissue development. Acts upstream of or within response to bacterium. Located in several cellular components, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Orthologous to human PLAAT3 (phospholipase A and acyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plaat3 |
| Official Name | phospholipase A and acyltransferase 3 [Source:MGI Symbol;Acc:MGI:2179715] |
| Ensembl ID | ENSMUSG00000060675 |
| Bio databases IDs | |
| Aliases | phospholipase A and acyltransferase 3 |
| Synonyms | ADPLA, FPLD9, HRASLS3, H-REV107, H-REV107-1, HREV107-3, HRSL3, MLP-3, phospholipase A and acyltransferase 3, PLA2G16, RLP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plaat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- phospholipase A1
- N-acyltransferase
- membrane-association domain
- NlpC/P60 family
- enzyme
- protein binding
- transferase, transferring acyl groups
- phospholipase A2
- phospholipase
Pathways
Biological processes and signaling networks where the Plaat3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- familial partial lipodystrophy type 9
- lipodystrophic and neurological syndrome
- tumorigenesis
- psoriasis
- diabetic nephropathy
- hepatic steatosis
- insulin resistance
- obesity
role in cell
- formation
- accumulation in
- formation in
- expression in
- proliferation
- migration
- cell cycle progression
- apoptosis
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- nuclear membrane fraction
- membrane fraction
- perinuclear region
- cellular membrane
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nuclear envelope
- peroxisomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plaat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- N-acylphosphatidylethanolamine metabolic process
- phosphatidylethanolamine acyl-chain remodeling
- peroxisome organization
- ether lipid metabolic process
- lipid catabolic process
- phospholipid biosynthetic process
- triglyceride metabolic process
- membrane disassembly
- lens fiber cell differentiation
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- lysosomal membrane
- plasma membrane
- lysosome
- nuclear envelope
- peroxisomal membrane
- endoplasmic reticulum membrane
- peroxisome
- mitochondrial membrane
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- transferase activity, transferring acyl groups
- protein binding
- phosphatidylserine 1-acylhydrolase activity
- lipid binding
- phosphatidylcholine 1-acylhydrolase activity
- N-acyltransferase activity