Hlf Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hlf |
| Official Name | hepatic leukemia factor [Source:MGI Symbol;Acc:MGI:96108] |
| Ensembl ID | ENSMUSG00000003949 |
| Bio databases IDs | |
| Aliases | hepatic leukemia factor |
| Synonyms | E230015K02Rik, hepatic leukaemia factor, hepatic leukemia factor, HLF transcription factor, PAR bZIP family member, LOC103693416, LOC690286 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hlf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- transcription activation domain
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Hlf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- epilepsy
- HER2 negative hormone receptor negative breast cancer
- gout
- squamous cell cancer
- glioblastoma
- glioblastoma cancer
- urticaria
- angioedema
- endometrial cancer
role in cell
- expression in
- apoptosis
- transcription in
- survival
- differentiation
- transactivation in
- morphology
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hlf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle cell differentiation
- rhythmic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity