Batf2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to protozoan and myeloid dendritic cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; central nervous system; dorsal root ganglion; lung; and spinal cord. Orthologous to human BATF2 (basic leucine zipper ATF-like transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Batf2 |
| Official Name | basic leucine zipper transcription factor, ATF-like 2 [Source:MGI Symbol;Acc:MGI:1921731] |
| Ensembl ID | ENSMUSG00000039699 |
| Bio databases IDs | |
| Aliases | basic leucine zipper transcription factor, ATF-like 2 |
| Synonyms | basic leucine zipper ATF-like transcription factor 2, basic leucine zipper transcription factor, ATF-like 2, RGD1311481, SARI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Batf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Basic region leucine zipper
- protein binding
- bZIP
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- organismal death
- neoplastic cell transformation
role in cell
- expression in
- activation in
- growth
- invasion
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Batf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myeloid dendritic cell differentiation
- defense response to protozoan
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity