Lmo2 Gene Summary [Mouse]
Enables chromatin binding activity. Contributes to DNA binding activity. Involved in negative regulation of erythrocyte differentiation. Acts upstream of or within embryonic hemopoiesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study acute lymphoblastic leukemia. Orthologous to human LMO2 (LIM domain only 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmo2 |
| Official Name | LIM domain only 2 [Source:MGI Symbol;Acc:MGI:102811] |
| Ensembl ID | ENSMUSG00000032698 |
| Bio databases IDs | |
| Aliases | LIM domain only 2 |
| Synonyms | LIM domain only 2, Lmos2, LOC100048263, RBTN2, RBTNL1, RHOM2, TCL2, TTG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- transcription co-activator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription factor binding
- chromatin binding
- protein binding
- identical protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- leukemia
- acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
- childhood T acute lymphoblastic leukemia
- organismal death
- cleft palate
- HER2 negative hormone receptor negative breast cancer
- adult T-cell acute lymphoblastic leukemia
role in cell
- expression in
- apoptosis
- proliferation
- transcription in
- differentiation
- colony formation by
- upregulation in
- development
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- protein binding
- transcription coactivator activity
- metal ion binding
- bHLH transcription factor binding