Dnaja3 Gene Summary [Mouse]
Enables GTPase regulator activity; receptor tyrosine kinase binding activity; and unfolded protein binding activity. Involved in skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within several processes, including activation-induced cell death of T cells; mitochondrial DNA replication; and positive regulation of T cell proliferation. Located in several cellular components, including cytoplasmic side of plasma membrane; neuromuscular junction; and postsynaptic membrane. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dnaja3 |
| Official Name | DnaJ heat shock protein family (Hsp40) member A3 [Source:MGI Symbol;Acc:MGI:1933786] |
| Ensembl ID | ENSMUSG00000004069 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member A3 |
| Synonyms | 1200003J13Rik, 1810053A11Rik, DNAJ3, DnaJ heat shock protein family (Hsp40) member A3, HCA57, hTID-1, TID1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnaja3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chaperone protein DnaJ
- mitochondrial presequence
- DnaJ central domain
- Hsp70 protein binding
- GTPase regulator
- protein kinase binding
- NF-kappaB binding
- transcription factor binding
- interferon-gamma receptor binding
- protein binding
- DnaJ domain
- Zinc finger domain of DnaJ and HSP40
- DnaJ
- DnaJ molecular chaperone homology domain
- binding protein
- receptor tyrosine kinase binding
- DnaJ C terminal domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Dnaja3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-small cell lung cancer
- migraines
- schizophrenia
- non-small cell lung carcinoma
- early onset hypertension
- systemic autoimmune syndrome
- impotence
- focal cortical dysplasia of Taylor
role in cell
- differentiation
- expression in
- apoptosis
- proliferation
- growth
- activation in
- production in
- degradation in
- cell death
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- insoluble fractions
- mitochondrial fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Mitochondria
- actin filaments
- cytosol
- cytoplasmic face of plasma membrane
- postsynaptic membrane
- mitochondrial matrix
- mitochondrial nucleoids
- neuromuscular junctions
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnaja3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- T cell differentiation in thymus
- negative regulation of cell proliferation
- cellular senescence
- mitochondrial DNA replication
- positive regulation of T cell proliferation
- protein folding
- mitochondrion organization
- negative regulation of transcription from RNA polymerase II promoter
- activation-induced cell death of T cells
- skeletal muscle acetylcholine-gated channel clustering
- response to heat
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic membrane
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- neuromuscular junction
- actin filament
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- metal ion binding
- GTPase regulator activity
- unfolded protein binding
- Hsp70 protein binding