Bcl2 Gene Summary [Mouse]
This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2 |
| Official Name | B cell leukemia/lymphoma 2 [Source:MGI Symbol;Acc:MGI:88138] |
| Ensembl ID | ENSMUSG00000057329 |
| Bio databases IDs | |
| Aliases | B cell leukemia/lymphoma 2 |
| Synonyms | B cell leukaemia/lymphoma 2, B cell leukemia/lymphoma 2, Bcl2 alpha, BCL2 apoptosis regulator, BCL2, apoptosis regulator, Bcl2 α, C430015F12Rik, D630044D05RIK, D830018M01RIK, LOC100046608, ORF16, PPP1R50 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- regulatory domain
- transcription factor binding
- identical protein binding
- Bcl-2 homology region 4
- Prp binding domain
- Bcl-2 homology 1 domain
- Caspase 3 cleavage site
- Bcl-2 homology 3 domain
- serine phosphorylation site
- loop domain
- apoptosis regulator
- ubiquitin protein ligase binding
- mitochondrial presequence
- protease binding
- channel/pore class transporter
- protein phosphatase binding
- negative regulatory domain
- alpha helix
- channel inhibitor
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- threonine phosphorylation site
- phosphorylation site
- BH3 binding domain
- binding protein
- flexible loop regulatory domain
- Bcl-2 homology 2 domain
- transmembrane domain
- protein heterodimerization
- transporter
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Bcl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Autophagy
- Ceramide Signaling
- Chronic Myeloid Leukemia Signaling
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EIF2 Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-7 Signaling Pathway
- IL-8 Signaling
- Induction of Apoptosis by HIV1
- Interferon Signaling
- Melanocyte Development and Pigmentation Signaling
- Molecular Mechanisms of Cancer
- p53 Signaling
- PEDF Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mantle cell lymphoma
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- neoplasia
- multiple sclerosis
- prostate cancer
- pain
- infection
- cancer
- epithelial cancer
phenotypes
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal L3 dorsal root ganglion morphology
- abnormal T cell differentiation
- abnormal T cell physiology
- abnormal cell adhesion
- abnormal coat/hair pigmentation
- abnormal facial motor nucleus morphology
- abnormal glomerular capillary endothelium morphology
- abnormal glomerular capsule parietal layer morphology
- abnormal immune system organ morphology
- abnormal induced retinal neovascularization
- abnormal kidney blood vessel morphology
- abnormal kidney cortex morphology
- abnormal kidney corticomedullary boundary morphology
- abnormal kidney development
- abnormal kidney interstitium morphology
- abnormal kidney medulla morphology
- abnormal kidney mesenchyme morphology
- abnormal kidney morphology
- abnormal leukopoiesis
- abnormal lymphocyte morphology
- abnormal lymphocyte physiology
- abnormal metanephric mesenchyme morphology
- abnormal metanephric ureteric bud development
- abnormal nephrogenic zone morphology
- abnormal optic nerve morphology
- abnormal pericyte morphology
- abnormal podocyte morphology
- abnormal primordial ovarian follicle morphology
- abnormal renal glomerulus morphology
- abnormal renal tubule epithelium morphology
- abnormal retinal vasculature morphology
- abnormal skeletal muscle fiber type ratio
- abnormal small intestinal villus morphology
- abnormal small intestine crypts of Lieberkuhn morphology
- abnormal small intestine morphology
- abnormal spleen morphology
- abnormal spleen red pulp morphology
- abnormal spleen white pulp morphology
- abnormal superior cervical ganglion morphology
- abnormal sympathetic neuron morphology
- abnormal thymus involution
- abnormal thymus morphology
- abnormal ureteric bud elongation
- absent hair follicle melanin granules
- absent oocytes
- cachexia
- decreased B cell number
- decreased B cell proliferation
- decreased CD8-positive alpha-beta T cell number
- decreased T cell number
- decreased body size
- decreased body weight
- decreased double-positive T cell number
- decreased glomerular capsule space
- decreased immature B cell number
- decreased kidney weight
- decreased lymphocyte cell number
- decreased mature B cell number
- decreased nephron number
- decreased pre-B cell number
- decreased renal glomerulus number
- decreased sensory neuron number
- decreased small intestinal villus height
- decreased spleen weight
- decreased spleen white pulp amount
- decreased thymocyte number
- decreased vascular endothelial cell number
- delayed kidney development
- dilated distal convoluted tubules
- dilated proximal convoluted tubules
- dilated renal tubules
- diluted coat color
- enlarged kidney
- enlarged lymph nodes
- enlarged spleen
- expanded mesangial matrix
- glomerulosclerosis
- hypopigmentation
- impaired branching involved in ureteric bud morphogenesis
- increased B cell apoptosis
- increased B cell derived lymphoma incidence
- increased B cell number
- increased T cell apoptosis
- increased blood urea nitrogen level
- increased circulating creatinine level
- increased compensatory renal growth
- increased double-negative T cell number
- increased follicular lymphoma incidence
- increased immature B cell number
- increased kidney apoptosis
- increased kidney cell proliferation
- increased mature B cell number
- increased metanephric mesenchyme apoptosis
- increased pre-B cell number
- increased renal glomerulus apoptosis
- increased splenocyte apoptosis
- irregular coat pigmentation
- kidney cortex cysts
- kidney cysts
- kidney degeneration
- kidney failure
- kidney medulla cysts
- mesangiolysis
- motor neuron degeneration
- pale kidney
- parietal capsular epithelium metaplasia
- podocyte foot process effacement
- podocyte hypertrophy
- polycystic kidney
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- renal glomerular synechia
- renal glomerulus hypertrophy
- renal hypoplasia
- renal tubule hypertrophy
- retinal ganglion cell degeneration
- round snout
- short ears
- short snout
- small ears
- small kidney
- small metanephros
- small spleen
- small thymus
- small ureteric bud
- spleen atrophy
- thymus atrophy
role in cell
- signaling in
- number
- maturation
- phosphorylation in
- cell death
- apoptosis
- inhibition in
- permeability transition
- production in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- soluble fraction
- endoplasmic reticulum fraction
- nuclear membrane fraction
- membrane fraction
- mitochondrial fraction
- intracellular compartment
- intracellular structures
- cytoskeleton
- cell surface
- intracellular space
- basal compartment
- perinuclear region
- intracellular membranes
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- granules
- cytosol
- endoplasmic reticulum membrane
- outer leaflet
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial outer membrane
- mitochondrial inner membrane
- nuclear envelope
- myelin sheath
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- post-embryonic development
- response to radiation
- actin filament organization
- induction of apoptosis via death domain receptors
- calcium ion transport into cytosol
- negative regulation of cellular pH reduction
- positive regulation of cell growth
- negative regulation of cell growth
- regulation of mitochondrial membrane potential
- axonogenesis
- humoral immune response
- regulation of calcium ion transport
- establishment of localization in cell
- neuron apoptotic process
- positive regulation of peptidyl-serine phosphorylation
- induction of apoptosis by oxidative stress
- DNA damage response, signal transduction resulting in induction of apoptosis
- response to hydrogen peroxide
- response to DNA damage stimulus
- regulation of mitochondrial membrane permeability
- cellular response to glucose starvation
- smooth muscle cell migration
- glomerulus development
- regulation of cell-matrix adhesion
- release of cytochrome c from mitochondria
- hair follicle morphogenesis
- positive regulation of B cell proliferation
- axon regeneration
- organ growth
- positive regulation of neuron maturation
- positive regulation of cell proliferation
- neuron maturation
- spleen development
- extrinsic apoptotic signaling pathway in absence of ligand
- response to xenobiotic stimulus
- positive regulation of multicellular organism growth
- thymus development
- negative regulation of neuron apoptotic process
- negative regulation of anoikis
- response to glucocorticoid stimulus
- negative regulation of G1/S transition of mitotic cell cycle
- B cell receptor signaling pathway
- negative regulation of reactive oxygen species metabolic process
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- T cell differentiation in thymus
- protein polyubiquitination
- CD8-positive, alpha-beta T cell lineage commitment
- gland morphogenesis
- digestive tract morphogenesis
- response to nicotine
- B cell homeostasis
- B cell apoptotic process
- behavioral fear response
- ovarian follicle development
- reactive oxygen species metabolic process
- metanephros development
- negative regulation of dendritic cell apoptotic process
- branching involved in ureteric bud morphogenesis
- negative regulation of B cell apoptotic process
- negative regulation of calcium ion transport into cytosol
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- negative regulation of apoptotic signaling pathway
- response to toxin
- lymphoid progenitor cell differentiation
- renal system process
- T cell homeostasis
- motor neuron apoptotic process
- dendritic cell apoptotic process
- ossification
- autophagy
- apoptotic process
- defense response to virus
- cellular response to hypoxia
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
- response to gamma radiation
- focal adhesion assembly
- negative regulation of motor neuron apoptotic process
- regulation of protein localization
- cochlear nucleus development
- mesenchymal cell development
- retinal cell programmed cell death
- B cell proliferation
- B cell lineage commitment
- negative regulation of T cell apoptotic process
- negative regulation of autophagy
- negative regulation of retinal cell programmed cell death
- T cell apoptotic process
- regulation of gene expression
- osteoblast proliferation
- regulation of nitrogen utilization
- negative regulation of osteoblast proliferation
- negative regulation of cell migration
- response to UV-B
- response to cytokine stimulus
- melanin metabolic process
- regulation of viral genome replication
- response to ischemia
- skeletal muscle fiber development
- regulation of glycoprotein biosynthetic process
- G1/S transition of mitotic cell cycle
- response to iron ion
- positive regulation of smooth muscle cell migration
- negative regulation of mitochondrial depolarization
- endoplasmic reticulum calcium ion homeostasis
- negative regulation of myeloid cell apoptotic process
- female pregnancy
- regulation of transmembrane transporter activity
- hemopoietic stem cell differentiation
- positive regulation of skeletal muscle fiber development
- stem cell development
- positive regulation of melanocyte differentiation
- melanocyte differentiation
- regulation of protein stability
- oocyte development
- pigment granule organization
- homeostasis of number of cells within a tissue
- ear development
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- negative regulation of ossification
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- pore complex
- endoplasmic reticulum
- mitochondrial outer membrane
- endoplasmic reticulum membrane
- nucleus
- nuclear membrane
- cytoplasm
- membrane
- BAD-BCL-2 complex
- mitochondrion
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- channel activity
- sequence-specific DNA binding
- protease binding
- BH domain binding
- BH3 domain binding
- protein binding
- ubiquitin protein ligase binding
- protein heterodimerization activity
- protein phosphatase 2A binding
- channel inhibitor activity
- binding, bridging