Mapk6 Gene Summary [Mouse]
Enables MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Involved in protein phosphorylation. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mapk6 |
| Official Name | mitogen-activated protein kinase 6 [Source:MGI Symbol;Acc:MGI:1354946] |
| Ensembl ID | ENSMUSG00000042688 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 6 |
| Synonyms | 2610021I23RIK, D130053K17Rik, ERK3, HsT17250, LOC112268149, Mapk4, Mapk63, mitogen-activated protein kinase 6, p97MAPK, Prkm4, PRKM6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- protein kinase binding
- catalytic domain
- protein binding
- Protein kinase domain
- activation loop
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- MAP kinase
- alcohol group acceptor phosphotransferase
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Mapk6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Neuroinflammation Signaling Pathway
- Opioid Signaling Pathway
- Phagosome Formation
- Role of Tissue Factor in Cancer
- Sirtuin Signaling Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- impaired glucose tolerance
- atelectasis
- intrauterine growth retardation
- psoriasis
- congenital hypoplasia of lung
- idiopathic scoliosis
- weight gain
- osteoarthritis
- insulin resistance
role in cell
- migration
- proliferation
- expression in
- binding in
- differentiation
- invasion
- interaction in
- development
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- signal transduction
- positive regulation of dendritic spine development
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- septin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein binding
- protein heterodimerization activity
- MAP kinase activity
- protein serine/threonine kinase activity