Slc2a9 Gene Summary [Mouse]
Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a9 |
| Official Name | solute carrier family 2 (facilitated glucose transporter), member 9 [Source:MGI Symbol;Acc:MGI:2152844] |
| Ensembl ID | ENSMUSG00000005107 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 (facilitated glucose transporter), member 9 |
| Synonyms | GLUT-9, GLUTX, SLC2a9A, SLC2A9B, solute carrier family 2 (facilitated glucose transporter), member 9, solute carrier family 2 member 9, UAQTL2, URATv1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc2a9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- phosphate:H+ symporter
- protein binding
- fructose transporter
- urate transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- tubulo-interstitial fibrosis
- gout
- renal hypouricemia type 2
- autosomal recessive renal hypouricemia type 2
- autosomal dominant renal hypouricemia type 2
- gestational diabetes mellitus
- cleft palate
- mumps
- kidney stones
regulates
- D-glucose
- adenosine triphosphate
- insulin
- uric acid
- Fru,Glc,urate
- magnesium
- Na+
- hexose
- K+
- adenine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- high-density microsomal fractions
- perinuclear region
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc2a9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- monosaccharide transport
- urate transport
- urate metabolic process
- hexose transport
- fructose transport
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane transporter activity
- urate transmembrane transporter activity
- sugar:hydrogen symporter activity
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity
- hexose transmembrane transporter activity