Nomo1 Gene Summary [Mouse]
Predicted to enable ribosome binding activity. Predicted to be involved in multi-pass transmembrane protein insertion into ER membrane. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; early embryo; and retina. Orthologous to several human genes including NOMO1 (NODAL modulator 1) and NOMO2 (NODAL modulator 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nomo1 |
| Official Name | nodal modulator 1 [Source:MGI Symbol;Acc:MGI:2385850] |
| Ensembl ID | ENSMUSG00000030835 |
| Bio databases IDs | |
| Aliases | nodal modulator 1 |
| Synonyms | D7Ertd156e, Nodal modulator 1, NODAL modulator 3, Nomo, Nomo1, pM5, RGD1305240 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nomo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribosome binding
- Peptidase_M14NE-CP-C_like
- protein binding
- CarboxypepD_reg-like domain
- Carboxypeptidase regulatory-like domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nomo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of left/right asymmetry in lateral mesoderm
- negative regulation of nodal signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding
- carbohydrate binding