Eps15l1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in synaptic vesicle endocytosis. Part of clathrin coat of coated pit. Is active in presynapse. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and sensory organ. Orthologous to human EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eps15l1 |
| Official Name | epidermal growth factor receptor pathway substrate 15-like 1 [Source:MGI Symbol;Acc:MGI:104582] |
| Ensembl ID | ENSMUSG00000006276 |
| Bio databases IDs | |
| Aliases | epidermal growth factor receptor pathway substrate 15-like 1 |
| Synonyms | 9830147J04Rik, AI593686, epidermal growth factor receptor pathway substrate 15-like 1, EPS15R, Eps15-rs, LOC103689946, LOC105372294 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eps15l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule-binding protein MIP-T3 C-terminal region
- YscO-like protein
- Nuf2, DHR10-like domain
- WTAP/Mum2p family
- B-Box C-terminal domain
- Domain of unknown function (DUF5082)
- Bin/Amphiphysin/Rvs domain
- Type III secretion protein YscO
- Laminin Domain I
- Prefoldin subunit
- STAT_CCD
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- iSH2_PI3K_IA_R
- SPEC
- DivIVA protein
- polo kinase kinase
- Domain of unknown function (DUF4515)
- TPR/MLP1/MLP2-like protein
- Bacterial type III secretion protein (HrpB7)
- Tropomyosin like
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- Domain of unknown function (DUF4618)
- Domain of unknown function (DUF4795)
- EFh
- protein binding
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- SynN
- MAP7 (E-MAP-115) family
- prefoldin
- Spectrin repeat
- Eps15 homology domain
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- Cytoskeletal-regulatory complex EF hand
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- growth failure
- aphagia
- cutaneous melanoma
- cutaneous melanoma cancer
- developmental delay
regulated by
- Caco2 cells
- mir-122 (includes others)
- EGF
- levodopa
- gabapentin
- tetrachlorodibenzodioxin
- metronidazole
- colistin
- gentamicin
- vancomycin
regulates
- REV
- SLC6A3
- FcER1
role in cell
- cell viability
- growth
- clustering
- endocytosis
- abnormal quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cellular membrane
- Nucleus
- cytosol
- synaptic vesicles
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eps15l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosomal transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- clathrin coat of coated pit
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cadherin binding