Pml Gene Summary [Mouse]
Enables SMAD binding activity. Involved in several processes, including defense response to other organism; regulation of macromolecule metabolic process; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and cellular response to cytokine stimulus. Located in PML body; cytosol; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pml |
| Official Name | promyelocytic leukemia [Source:MGI Symbol;Acc:MGI:104662] |
| Ensembl ID | ENSMUSG00000036986 |
| Bio databases IDs | |
| Aliases | promyelocytic leukemia |
| Synonyms | 1200009E24Rik, AI661194, PML nuclear body scaffold, PP8675, promyelocytic leukaemia, promyelocytic leukemia, RGD1562602, RNF71, TRIM19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pml often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- zinc-binding active site
- transcription co-activator
- Sumoylation motif
- EXOIII
- coiled-coil domain
- leucine zipper domain
- Hdac1 binding domain
- identical protein binding
- SUMO binding domain
- proline rich domain
- B2 box domain
- YSPTSPS repeat
- Box I domain
- zinc ion binding
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- B1 box
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ligand-dependent nuclear receptor
- B-box zinc finger
- zinc-RING finger domain
- Protein of unknown function (DUF3583)
- serine-proline rich domain
- ubiquitin protein ligase binding
- Centrosome localization domain of PPC89
- dimerization domain
- SUMO transferase activity
- RING B-box domain
- nuclear localization sequence
- alpha helix
- protein binding
- transition metal ion binding
- B-box-type zinc finger superfamily
- protein homodimerization
- serine threonine rich domain
- zinc finger domain
- Box B domain
- Apolipoprotein A1/A4/E domain
- protein heterodimerization
- TRIM domain
- Zinc finger, C3HC4 type (RING finger)
- SUMO-1 modification site
Pathways
Biological processes and signaling networks where the Pml gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- epithelial neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- metastasis
- schizoaffective disorder
- unspecified disease
role in cell
- activation in
- expression in
- proliferation
- apoptosis
- morphology
- cell death
- phosphorylation in
- binding in
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nuclear matrix fraction
- ND10 structure
- Cytoplasm
- perinuclear region
- granules
- cytosol
- nuclear foci
- dense fibrillar component
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
- nuclear speckles
- nuclear matrix
- clastosomes
- early endosomes
- PML nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pml gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of angiogenesis
- protein sumoylation
- negative regulation of cell proliferation
- cellular senescence
- negative regulation of interleukin-1 beta production
- transforming growth factor beta receptor signaling pathway
- extrinsic apoptotic signaling pathway
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- response to UV
- regulation of circadian rhythm
- branching involved in mammary gland duct morphogenesis
- circadian regulation of gene expression
- retinoic acid receptor signaling pathway
- response to hypoxia
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- regulation of double-strand break repair
- positive regulation of fibroblast proliferation
- positive regulation of peptidyl-lysine acetylation
- entrainment of circadian clock by photoperiod
- cellular response to interleukin-4
- endoplasmic reticulum calcium ion homeostasis
- response to gamma radiation
- positive regulation of telomere maintenance
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- oncogene-induced senescence
- macromolecular complex assembly
- SMAD protein signal transduction
- regulation of transcription, DNA-dependent
- induction of apoptosis by oxidative stress
- DNA damage response, signal transduction resulting in induction of apoptosis
- protein complex localization
- proteasomal ubiquitin-dependent protein catabolic process
- innate immune response
- protein import into nucleus
- cell fate commitment
- myeloid cell differentiation
- regulation of calcium ion transport into cytosol
- positive regulation of extrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- regulation of cell adhesion
- fibroblast migration
- maintenance of protein location in nucleus
- PML body organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- chromosome, telomeric region
- nucleus
- PML body
- cytoplasm
- cytosol
- nuclear matrix
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- SUMO binding
- zinc ion binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- SMAD binding
- binding, bridging
- SUMO ligase activity