Fcho2 Gene Summary [Mouse]
Enables identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and phosphatidylserine binding activity. Involved in membrane invagination; protein localization to plasma membrane; and synaptic vesicle endocytosis. Located in clathrin-coated vesicle and plasma membrane. Is active in clathrin-coated pit. Is expressed in endolymphatic appendage and head. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Fcho2 |
| Official Name | FCH domain only 2 [Source:MGI Symbol;Acc:MGI:3505790] |
| Ensembl ID | ENSMUSG00000041685 |
| Bio databases IDs | |
| Aliases | FCH domain only 2 |
| Synonyms | 5832424M12Rik, FCH and mu domain containing endocytic adaptor 2, FCH domain only 2, LOC100364209, RGD1565396 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcho2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- Vps5 C terminal like
- phosphatidylinositol-4,5-bisphosphate binding
- AP_MHD_Cterm
- Muniscin C-terminal mu homology domain
- Mu-homology domain
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary central nervous system lymphoma
- acne
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- primary cancer
- lymphomagenesis
- central nervous system cancer
- brain cancer
- small cell lung carcinoma
- small cell lung cancer
role in cell
- replication in
- assembly
- quantity
- endocytosis by
- clustering in
- size
- endocytosis
- invagination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- synaptic membrane
- synapse
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fcho2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- clathrin coat assembly
- synaptic vesicle endocytosis
- membrane invagination
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- coated pit
- cytosol
- clathrin-coated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- phosphatidylinositol binding