Cdh1 Gene Summary [Mouse]
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cdh1 |
| Official Name | cadherin 1 [Source:MGI Symbol;Acc:MGI:88354] |
| Ensembl ID | ENSMUSG00000000303 |
| Bio databases IDs | |
| Aliases | cadherin 1 |
| Synonyms | ARC-1, BCDS1, cadherin 1, Cadherin E, CD324, CDHE, CSEIL, ECAD, E-cadherin, L-CAM, Um, UVO, uvomorulin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-catenin binding
- Cadherin-like repeat
- cell adhesion molecule binding
- calcium binding loop
- identical protein binding
- membrane distal domain
- p120-catenin binding domain
- cytoskeletal protein binding
- serine-rich region
- alpha catenin-binding domain
- ankyrin binding
- cytoplasmic domain
- Cadherin repeat-like domain
- intracellular domain
- membrane-proximal domain
- G12 binding domain
- beta-catenin binding domain
- extracellular domain
- RVL motif
- protein kinase binding
- beta-catenin binding
- protein phosphatase binding
- ectodomain
- calcium ion binding
- central domain
- protein domain specific binding
- protein binding
- acidic domain
- phosphorylation site
- Cadherin, Y-type LIR-motif
- CH2 domain (from immunoglobulin)
- gamma catenin binding domain
- gamma-catenin binding
- Cadherin prodomain like
- transmembrane domain
- cell adhesion recognition domain
- catenin binding domain
- cytosolic tail domain
- charged domain
- extracellular cadherin structural domain
Pathways
Biological processes and signaling networks where the Cdh1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endometrial Cancer Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Gα12/13 Signaling
- IL-8 Signaling
- ILK Signaling
- Melanoma Signaling
- Molecular Mechanisms of Cancer
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Remodeling of Epithelial Adherens Junctions
- RhoGDI Signaling
- Serotonin Receptor Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Sirtuin Signaling Pathway
- Thyroid Cancer Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-small cell lung cancer
- neoplasia
- hereditary cancer-predisposing syndrome
- diffuse gastric and lobular breast cancer syndrome
- congenital cystic adenomatoid malformation
- cutaneous melanoma
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- growth
- expression in
- apoptosis
- accumulation in
- cell death
- binding in
- ubiquitination in
- differentiation
- activation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- plasma membrane fraction
- soluble fraction
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- insoluble fractions
- glutaminergic synapse
- cell junction
- cortical actin cytoskeleton
- apical extension
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- postsynaptic region
- membrane surface
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Nucleus
- endosomes
- vesicles
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytosol
- lateral cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- cytoplasmic face of plasma membrane
- endoplasmic reticulum buds
- caveolar membranes
- apical membrane
- basolateral membrane
- lateral plasma membrane
- trans Golgi network
- nodes of Ranvier
- paranodal loops
- paranodes
- myelin sheath
- Schmidt-Lanterman incisures
- periplasmic membranes
- early endosomes
- perinuclear vesicles
- anchoring junction
- tight junctions
- junctional complexes
- zonula adherens
- lateral cell-cell contacts
- microvilli
- cell membrane leading edge
- axons
- axon terminals
- cell-cell adherens junctions
- plasma
- lamellipodia
- macropinosomes
- detergent-soluble fraction
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- calcium-dependent cell-cell adhesion
- adherens junction organization
- cell-cell junction assembly
- neuron projection development
- multicellular organismal development
- cell morphogenesis
- negative regulation of cell-cell adhesion
- homophilic cell adhesion
- response to xenobiotic stimulus
- response to toxin
- pituitary gland development
- cellular response to lithium ion
- cellular response to indole-3-methanol
- synapse assembly
- positive regulation of transcription, DNA-dependent
- negative regulation of axon extension
- cell-cell adhesion mediated by cadherin
- regulation of gene expression
- cell migration
- negative regulation of cell migration
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- extracellular region
- plasma membrane
- internal side of plasma membrane
- adherens junction
- trans-Golgi network
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- membrane
- apical junction complex
- actin cytoskeleton
- cell junction
- catenin complex
- cortical actin cytoskeleton
- flotillin complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- gamma-catenin binding
- identical protein binding
- protein binding
- ankyrin binding
- cadherin binding
- calcium ion binding
- cell adhesion molecule binding
- GTPase activating protein binding
- beta-catenin binding