Dync1li2 Gene Summary [Mouse]
Predicted to enable dynein heavy chain binding activity and identical protein binding activity. Acts upstream of or within centrosome localization and microtubule cytoskeleton organization. Predicted to be located in kinetochore and late endosome. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dync1li2 |
| Official Name | dynein, cytoplasmic 1 light intermediate chain 2 [Source:MGI Symbol;Acc:MGI:107738] |
| Ensembl ID | ENSMUSG00000035770 |
| Bio databases IDs | |
| Aliases | dynein, cytoplasmic 1 light intermediate chain 2 |
| Synonyms | AA409702, C920003I06, Dlic2, DNCLI2, Dnclic2, dynein cytoplasmic 1 light intermediate chain 2, dynein, cytoplasmic 1 light intermediate chain 2, LIC2, LIC53/55 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dync1li2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein light intermediate chain (DLIC)
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Dync1li2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cohesion
- formation
- dispersal
- organization
- cohesion in
- formation in
- stability
- localization
- dispersal in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- Golgi membrane
- late endosomes
- kinetochores
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dync1li2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- microtubule cytoskeleton organization
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasmic dynein complex
- centrosome
- membrane
- late endosome
- dynein complex
- cytosol
- kinetochore
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- dynein heavy chain binding