Ankrd26 Gene Summary [Mouse]
Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human ANKRD26 (ankyrin repeat domain containing 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankrd26 |
| Official Name | ankyrin repeat domain 26 [Source:MGI Symbol;Acc:MGI:1917887] |
| Ensembl ID | ENSMUSG00000007827 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 26 |
| Synonyms | 5730521P14Rik, ankyrin repeat domain 26, BC008111, mKIAA1074 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ankrd26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- Ankyrin repeats (many copies)
- CCDC144C protein coiled-coil region
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Domain of unknown function (DUF3496)
- Ankyrin repeats (3 copies)
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Ankyrin repeat
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- centrosome