Ptbp3 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and thymus primordium. Orthologous to human PTBP3 (polypyrimidine tract binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptbp3 |
| Official Name | polypyrimidine tract binding protein 3 [Source:MGI Symbol;Acc:MGI:1923334] |
| Ensembl ID | ENSMUSG00000028382 |
| Bio databases IDs | |
| Aliases | polypyrimidine tract binding protein 3 |
| Synonyms | 5830471K22Rik, circPTBP3, circRNA-PTBP3, polypyrimidine tract binding protein 3, ROD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RRM-like domain
- RNA recognition motif (RRM) superfamily
- hnRNP-L/PTB/hephaestus splicing factor family
- RNA recognition motif
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- metastasis
- schizophrenia
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- panic disorder
- organismal death
- non-small cell lung cancer
role in cell
- proliferation
- expression in
- colony formation
- migration
- differentiation
- invasion by
- cell proliferation
- splicing by
- tubulin inhibitor 6 sensitivity
- apico-basal polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of cell differentiation
- regulation of RNA splicing
- anatomical structure morphogenesis
- mRNA processing
- negative regulation of RNA splicing
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA binding