Man1a2 Gene Summary [Mouse]
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within glycoprotein metabolic process; lung alveolus development; and respiratory gaseous exchange by respiratory system. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Man1a2 |
| Official Name | mannosidase, alpha, class 1A, member 2 [Source:MGI Symbol;Acc:MGI:104676] |
| Ensembl ID | ENSMUSG00000008763 |
| Bio databases IDs | |
| Aliases | mannosidase, alpha, class 1A, member 2 |
| Synonyms | MAN1B, mannosidase alpha class 1A member 2, mannosidase, alpha, class 1A, member 2, mannosidase α class 1A member 2, mannosidase, α, class 1A, member 2, PCR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- non-insulin-dependent diabetes mellitus
- insomnia
- cyanosis
- dyspnea
- migraines
- pneumonia
- preeclampsia
- atelectasis
- postmenopausal osteoporosis
regulates
- N-glycan
- glycoprotein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man1a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- lung alveolus development
- N-glycan processing
- protein glycosylation
- respiratory gaseous exchange
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity